Author : 1 Mona H. Tawfek, 2 Safaa A. El-Gabrty, 3 Marwa F. Ahmed, 4 Rasha H. 5 Soliman, Sahar A. Sharaf, 6 Azza A. Helmy

Evidences reveal that vitamin D deficiency and vitamin D receptor gene polymorphism can influence the cognitive abilities of the normal aged subjects. The study was conducted on 50 non demented subjects ≥ 60 years old. Global assessment of cognitive function by: Modified Mini-Mental State examination test (3MS; Addenbrooke’s Cognitive Examination Revised). Assessment of specific cognitive functions; for attention: Paced Auditory Serial Addition Test and Trail B Test. Memory: Story A from logical memory subtest of the Wechsler Memory Scale-Revised, Paired Associate learning test and Benton Visual Retention test. Language: Token test. Visuospatial abilities: Block Design test. Measurement of 25 hydroxy vitamin D in serum and genotyping using PCR to detect the polymorphisms of VDRApaI and VDR-TaqI was done. Vitamin D deficiency was found to be associated with poor performance in tests assessing memory and attention, but no relation was with performance in executive functions, language or visuospatial abilities. VDR-ApaI polymorphism was found to affect memory and psychomotor speed but no effect on the performance in tests assessing attention, executive functions, language or visuospatial abilities. No effect for VDR-TaqI polymorphism on the performance in different tests. So, vitamin Vitamin D deficiency and vitamin D receptor gene polymorphism play an important role in exacerbating cognitive impairment of normal aging.

Affiliation :

1  Neurology Department, Faculty of Medicine, Bani-suef University, Bani-suef, Egypt.     

2  Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Giza, Egypt.   

3  Neurology Department, Faculty of Medicine, Cairo University, Giza, Egypt.       

      * marwafarghali@kasralainy.edu.eg        ** saharabdelattysharaf@yahoo.com

Corresponding author: Safaa A. El-Gabrty

E-mail: safaaelgabrty@yahoo.com

Keywords : Vitamin D, vitamin D receptor gene polymorphism, cognition, elderly.
Date : Sunday ,01 ,March ,2015

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